Brain network dynamics in patients with single‐ and multiple‐domain amnestic mild cognitive impairment
Individual functional network parcellations and coactivation pattern (CAP) analysis were performed to characterize spatiotemporal differences between single- and multiple-domain amnestic mild cognitive impairment (SD-aMCI and MD-aMCI), and between distinct aMCI subtypes and Alzheimer's disease (AD). The analysis of multicenter datasets converged on four pairs of recurrent CAPs, including primary sensory networks (PSN)-dominant CAPs, high-order cognitive networks (HOCN)-dominant CAPs, and PSN-HOCN-interacting CAPs. The HOCN and PSN are distinctively involved in aMCI subtypes and in the transformation between distinct aMCI subtypes and AD.
Authors
- Jian Zhang (ORCID: https://orcid.org/0000-0001-7681-8747)
- Jianghong Liu (ORCID: https://orcid.org/0000-0002-8405-6153)
- Shintaro Funahashi (ORCID: https://orcid.org/0000-0002-5781-0261)
- Tianyi Yan (ORCID: https://orcid.org/0000-0002-2674-4134)
- Chuyang Ye (ORCID: https://orcid.org/0000-0001-5839-1559)
- Li Wang (ORCID: https://orcid.org/0000-0001-6125-6972)
- Tiantian Liu (ORCID: https://orcid.org/0000-0001-5384-0642)
- Mingjun Wang (ORCID: https://orcid.org/0000-0002-5848-0444)
Institutions
- Beijing Institute of Technology (CN)
- Capital Medical University (CN)
- Kyoto University (JP)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/alz.14227
- Citations
- 5
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Beijing Municipality
- Beijing Municipal Natural Science Foundation
- Fundamental Research Funds for the Central Universities