<scp>GLT</scp>‐1 downregulation in hippocampal astrocytes induced by type 2 diabetes contributes to postoperative cognitive dysfunction in adult mice
These findings suggest that the adult mice with type 2 diabetes are at an increased risk of developing POCD, perhaps due to the downregulation of GLT-1 in hippocampal astrocytes, which enhances increased glutamatergic neuron excitability induced by A/S and leads to oxidative stress reaction, and neuronal apoptosis.
Authors
- Chenghua Zhou (ORCID: https://orcid.org/0000-0001-9879-8679)
- Lin‐Hui Ma
- Chunhui Jin (ORCID: https://orcid.org/0000-0002-8795-9542)
- Xin‐Hao Jiao
- Jie Wan (ORCID: https://orcid.org/0000-0001-8198-4985)
- Yuqing Wu (ORCID: https://orcid.org/0000-0001-8485-5951)
- Ziyi Li (ORCID: https://orcid.org/0000-0003-0947-9137)
- Wei Dong (ORCID: https://orcid.org/0000-0003-3900-6138)
- Qiang Liu (ORCID: https://orcid.org/0000-0002-5451-4862)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2104-534X)
- Weifeng Wu (ORCID: https://orcid.org/0000-0003-0818-4070)
- Sun Ao
- Yiqi Liu (ORCID: https://orcid.org/0000-0003-3956-4770)
- Yue Zhou (ORCID: https://orcid.org/0000-0001-5256-7736)
Institutions
- Tongji University (CN)
- Xuzhou Medical College (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1111/cns.70024
- Citations
- 13
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.48
Funders
- National Natural Science Foundation of China