Dysregulated neutrophil extracellular traps and haemostatic biomarkers as diagnostic tools and therapeutic targets in periprosthetic joint infection
We confirmed that patients with PJI have an increased level of NETosis in plasma. Their plasma both induced NET release and had an impaired ability to degrade NETs mediated by a reduced DNaseI activity. This can be therapeutically restored in vitro with the approved Dornase alfa, Pulmozyme, which may allow novel methods of treatment. A combination of NETs and haemostatic biomarkers could improve the diagnosis of PJI, especially those patients in whom this diagnosis is uncertain.
Authors
- Raquel Herranz (ORCID: https://orcid.org/0000-0002-0894-2946)
- Pilar Medina (ORCID: https://orcid.org/0000-0001-9637-5998)
- Emma Plana (ORCID: https://orcid.org/0000-0002-8457-6984)
- P Verger (ORCID: https://orcid.org/0009-0002-8768-331X)
- Francisco Raga Baixauli (ORCID: https://orcid.org/0000-0001-6170-8078)
- Júlia Oto (ORCID: https://orcid.org/0000-0003-3963-8661)
- José Vicente Amaya Valero (ORCID: https://orcid.org/0000-0002-8141-1199)
- Manuel Fuertes
Institutions
- Hospital Universitari i Politècnic La Fe (ES)
Publication Details
- Journal
- The Bone & Joint Journal
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1302/0301-620x.106b9.bjj-2024-0187.r1
- Citations
- 4
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.96