Dietary Zn proteinate with moderate chelation strength alleviates heat stress-induced intestinal barrier function damage by promoting expression of tight junction proteins via the A20/NF-κB p65/MMP-2 pathway in the jejunum of broilers
Our results suggest that dietary Zn, especially 60 mg Zn/kg as Zn-Prot M, can alleviate HS-induced intestinal barrier function damage by promoting the expression of TJ proteins possibly via induction of A20-mediated suppression of the NF-κB p65/MMP-2 pathway in the jejunum of HS broilers.
Authors
- Hsiao‐Ching Liu
- Xiudong Liao
- Jack Odle (ORCID: https://orcid.org/0000-0003-4965-2096)
- Shengchen Wang (ORCID: https://orcid.org/0000-0001-5686-7971)
- Xiaoyan Cui
- M. T. See (ORCID: https://orcid.org/0000-0002-1762-0439)
- Weiyun Zhang (ORCID: https://orcid.org/0009-0002-0937-6672)
- Liyang Zhang (ORCID: https://orcid.org/0000-0002-4054-1667)
- Tingting Li (ORCID: https://orcid.org/0000-0002-6319-9518)
- Xi Lin (ORCID: https://orcid.org/0000-0003-3911-9677)
- Sufen Li (ORCID: https://orcid.org/0000-0002-2695-8263)
- Ke Yang (ORCID: https://orcid.org/0009-0002-5117-680X)
- Yun Hu
- Yangyang Hu (ORCID: https://orcid.org/0009-0001-1412-9185)
- Xugang Luo
Institutions
- North Carolina State University (US)
- Chinese Academy of Agricultural Sciences (CN)
- Hebei Normal University of Science and Technology (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1186/s40104-024-01075-8
- Citations
- 12
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 4.09
Funders
- National Natural Science Foundation of China
- Yangzhou University