Y-27632 enables long-term expansion of mouse submandibular gland epithelial cells via inactivation of TGF-β1/CTGF/p38 and ROCK2/JNK signaling pathway
The TGF-β1/CTGF/p38 and ROCK2/JNK signaling pathways are responsible for SG-Epis proliferation, and Y-27632 treatment effectively inactivates these pathways, enabling long-term in vitro maintenance of SG-Epis. The culture method utilizing Y-27632 provides an effective approach for the in vitro expansion of SG-Epis.
Authors
- Sangho Roh (ORCID: https://orcid.org/0000-0001-8082-6459)
- Hyewon Kim (ORCID: https://orcid.org/0000-0002-0558-0281)
- Naeun Oh (ORCID: https://orcid.org/0000-0002-8952-4833)
- Kichul Kim
Institutions
- Seoul National University (KR)
- National University College (PR)
- Seoul National University Dental Hospital (KR)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.job.2024.08.005
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea