Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment
As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial. Here, we generated induced pluripotent stem cells (iPSCs) from Peripheral Blood Mononuclear Cells (PBMCs) retrieved from four ADHD patients (two MPH responders and two non-responders) using Sendai virus. These lines might be helpful for the in vitro investigation of ADHD pathophysiology in a patient-specific manner.
Authors
- Anna Maria Werling (ORCID: https://orcid.org/0000-0001-8998-7902)
- Susanne Walitza (ORCID: https://orcid.org/0000-0002-8161-8683)
- Per Hoffmann (ORCID: https://orcid.org/0000-0002-6573-983X)
- Michelle Rickli
- Stefan Herms (ORCID: https://orcid.org/0000-0002-2786-8200)
- Cristine Marie Yde Ohki (ORCID: https://orcid.org/0000-0002-7414-2250)
- Belén Rubio (ORCID: https://orcid.org/0000-0003-0858-1842)
- Edna Grünblatt (ORCID: https://orcid.org/0000-0001-8505-7265)
- Natalie Monet Walter
- Cedric Iseli
- Christian Döring
Institutions
- University of Bonn (DE)
- University of Basel (CH)
- University of Zurich (CH)
- University Hospital Bonn (DE)
- ETH Zurich (CH)
- University Hospital of Zurich (CH)
- Swiss Integrative Center for Human Health (CH)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.scr.2024.103546
- Citations
- 2
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.77