Hydrogen attenuates ischaemia–reperfusion injury in skeletal muscles post-limb replantation by activating the NRF2/HO-1 signalling pathway to reduce BAX expression
Pre-perfusion with hydrogen-rich heparin sodium markedly diminishes the BAX/Caspase-3-mediated apoptotic pathway in skeletal muscle tissues with IRI through the excitation of the NRF2/HO-1 pathway.
Authors
- Yongli Zhang (ORCID: https://orcid.org/0000-0002-2113-0387)
- Yu Wang (ORCID: https://orcid.org/0000-0002-6755-445X)
- Xiaoling Li (ORCID: https://orcid.org/0000-0002-3408-7066)
- Zihao Jiang
- Jinling Wang (ORCID: https://orcid.org/0000-0002-2723-8989)
- Zhicheng Yang (ORCID: https://orcid.org/0000-0002-7580-5183)
- Jiaqin Zheng
- jun-sheng Wang
- Mengqiu Xu
Institutions
- Guangdong Medical College (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37018
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xiamen University