Long-term effect of mavacamten in obstructive hypertrophic cardiomyopathy
Long-term mavacamten treatment resulted in sustained improvements in cardiac function and symptoms in patients with obstructive HCM, with no new safety concerns identified. Transient, reversible reductions in LVEF were observed in a small proportion of patients during long-term follow-up.
Authors
- Morten K. Jensen (ORCID: https://orcid.org/0000-0003-1144-4603)
- Roberto Barriales‐Villa (ORCID: https://orcid.org/0000-0002-6721-3487)
- Artur Oręziak (ORCID: https://orcid.org/0000-0003-3318-3643)
- Ganesh Balaratnam
- Wojciech Wojakowski (ORCID: https://orcid.org/0000-0002-3681-5207)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Shawna Fox
- Ashish H. Shah (ORCID: https://orcid.org/0000-0002-9396-7178)
- ANJALI TIKU OWENS (ORCID: https://orcid.org/0000-0002-9669-8495)
- Tim Seidler (ORCID: https://orcid.org/0000-0002-6158-5087)
- Matthew Thomas Wheeler (ORCID: https://orcid.org/0000-0001-8721-3022)
- Albert Hagège (ORCID: https://orcid.org/0000-0003-4685-6077)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Sheila M. Hegde (ORCID: https://orcid.org/0000-0001-8157-8899)
- Lubna Choudhury (ORCID: https://orcid.org/0000-0003-4039-8490)
- Andrew Wang (ORCID: https://orcid.org/0000-0001-8729-0933)
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0003-3411-1334)
- Neal K. Lakdawala
Institutions
- Northwestern University (US)
- Brigham and Women's Hospital (US)
- Oregon Health & Science University (US)
- Medical University of Silesia (PL)
- University of California, San Francisco (US)
- Universidad Francisco de Vitoria (ES)
- Aarhus University Hospital (DK)
- Spanish National Centre for Cardiovascular Research (ES)
- Bristol-Myers Squibb (United States) (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Meyer Children's Hospital (IL)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Hôpital Européen (FR)
- Universitätsmedizin Göttingen (DE)
- The Arrhythmia Institute (US)
- Kerckhoff Klinik (DE)
- Stanford Medicine (US)
- Complexo Hospitalario Universitario A Coruña (ES)
- Duke University Hospital (US)
- Instituto de Investigación Biomédica de A Coruña (ES)
- University of Göttingen (DE)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1093/eurheartj/ehae579
- Citations
- 79
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 31.76
Funders
- American Heart Association
- Bristol-Myers Squibb
- Pfizer
- Brigham and Women's Hospital
- Boston Scientific Corporation
- Cytokinetics
- Amicus Therapeutics