Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy
The CMR substudy of SEQUOIA-HCM demonstrated that treatment with aficamten relative to placebo for 24 weeks resulted in favorable cardiac remodeling. These changes, particularly with regard to LV mass, wall thickness, and left atrial size, could potentially lead to reduced cardiovascular events including heart failure and atrial fibrillation with longer follow-up. (Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM [SEQUOIA-HCM]; NCT05186818).
Authors
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0001-8966-6906)
- Artur Oręziak (ORCID: https://orcid.org/0000-0003-3318-3643)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- Michelle Michels (ORCID: https://orcid.org/0000-0001-6432-0431)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Amy Wohltman
- Christopher M. Kramer (ORCID: https://orcid.org/0000-0003-2057-7731)
- Caroline Coats (ORCID: https://orcid.org/0000-0002-3208-470X)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Matthew M.Y. Lee (ORCID: https://orcid.org/0000-0001-9213-2067)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Ian J. Kulac (ORCID: https://orcid.org/0000-0002-0710-1088)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Sheila M. Hegde (ORCID: https://orcid.org/0000-0001-8157-8899)
- Lisa Meng (ORCID: https://orcid.org/0000-0003-0229-1131)
- Raymond Y. Kwong (ORCID: https://orcid.org/0000-0001-8212-0759)
- Rhanderson Cardoso (ORCID: https://orcid.org/0000-0003-3622-7605)
- Béla Péter Merkely (ORCID: https://orcid.org/0000-0001-6514-0723)
Institutions
- Semmelweis University (HU)
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- Erasmus MC (NL)
- Lahey Medical Center (US)
- Meyer Children's Hospital (IT)
- Institute of Cardiology (PL)
- Cytokinetics (United States) (US)
- University of Virginia (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.jacc.2024.08.015
- Citations
- 50
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 20.10
Funders
- Cytokinetics