Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Compared with placebo, patients receiving aficamten demonstrated significant improvement in LVOT gradients and measures of LV diastolic function, and several of these measures were associated with improvements in pVO<sub>2</sub>, KCCQ-CSS, and NT-proBNP. A modest decrease in LVEF occurred yet remained within normal range. These findings suggest aficamten improved multiple structural and physiological parameters in oHCM without significant adverse changes in LV systolic function. (Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM [SEQUOIA-HCM]; NCT05186818).
Authors
- Theodore P. Abraham (ORCID: https://orcid.org/0000-0001-8966-6906)
- Roberto Barriales‐Villa (ORCID: https://orcid.org/0000-0002-6721-3487)
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- Narayana Prasad (ORCID: https://orcid.org/0000-0002-6280-2741)
- Sara Saberi (ORCID: https://orcid.org/0000-0003-4473-6725)
- Iacopo Olivotto (ORCID: https://orcid.org/0000-0003-1751-9266)
- Amy Wohltman
- Nuno Cardim (ORCID: https://orcid.org/0000-0002-3812-4872)
- Christopher M. Kramer (ORCID: https://orcid.org/0000-0003-2057-7731)
- Caroline Coats (ORCID: https://orcid.org/0000-0002-3208-470X)
- Michelle Michels
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Ahmad Masri (ORCID: https://orcid.org/0000-0002-6390-6526)
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Karola Jering (ORCID: https://orcid.org/0000-0002-5243-1959)
- Sheila M. Hegde (ORCID: https://orcid.org/0000-0001-8157-8899)
- Lisa Meng (ORCID: https://orcid.org/0000-0003-0229-1131)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
- Xiaowen Wang (ORCID: https://orcid.org/0000-0003-4623-1608)
- Farideh Roshanali
Institutions
- Brigham and Women's Hospital (US)
- Oregon Health & Science University (US)
- University of California, San Francisco (US)
- University of Virginia Health System (US)
- Lahey Medical Center (US)
- Meyer Children's Hospital (IT)
- Michigan Medicine (US)
- Centro de Investigación Biomédica en Red (ES)
- Cytokinetics (United States) (US)
- Complexo Hospitalario Universitario A Coruña (ES)
- Instituto de Investigación Biomédica de A Coruña (ES)
- Hospital do Desterro (PT)
- University of Missouri–Kansas City (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.jacc.2024.08.002
- Citations
- 33
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 13.27
Funders
- Cytokinetics