Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy
In patients with symptomatic oHCM, treatment with aficamten resulted in markedly improved health status, including significant improvement in chest pain-related health status, than placebo. (Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCM [SEQUOIA-HCM]; NCT05186818).
Authors
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Stephen B. Heitner (ORCID: https://orcid.org/0000-0003-2189-1474)
- John A. Spertus (ORCID: https://orcid.org/0000-0002-2839-2611)
- Sara Saberi (ORCID: https://orcid.org/0000-0003-4473-6725)
- Amy Wohltman
- Caroline Coats (ORCID: https://orcid.org/0000-0002-3208-470X)
- Martin S. Maron (ORCID: https://orcid.org/0000-0002-9923-3853)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- Daniel Jacoby (ORCID: https://orcid.org/0000-0002-9182-275X)
- Michael Butzner (ORCID: https://orcid.org/0000-0002-6015-7910)
- Iacopo Olivotto
- Fady I. Malik (ORCID: https://orcid.org/0000-0002-5597-5759)
- Stuart Kupfer (ORCID: https://orcid.org/0000-0002-5469-1287)
- Zi Michael Miao (ORCID: https://orcid.org/0000-0002-2377-1444)
- Charles F Sherrod
- Lisa Meng (ORCID: https://orcid.org/0000-0003-0229-1131)
- Michael E. Nassif (ORCID: https://orcid.org/0000-0002-1232-7604)
- Changsheng Ma (ORCID: https://orcid.org/0000-0002-3612-7367)
- Josef Veselka (ORCID: https://orcid.org/0000-0003-3597-3155)
- Gregory D. Lewis
- James L. Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
Institutions
- Brigham and Women's Hospital (US)
- Saint Luke's Health System (US)
- Harvard University (US)
- Capital Medical University (CN)
- Massachusetts General Hospital (US)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Lahey Medical Center (US)
- Baim Institute for Clinical Research (US)
- Meyer Children's Hospital (IT)
- Michigan Medicine (US)
- Centro de Investigación Biomédica en Red (ES)
- Beijing Anzhen Hospital (CN)
- Saint Luke's Hospital (US)
- Cytokinetics (United States) (US)
- Klinikum Chemnitz (DE)
- University of Missouri–Kansas City (US)
- Technische Universität Dresden (DE)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.jacc.2024.08.014
- Citations
- 21
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.44
Funders
- Cytokinetics