Asundexian versus Apixaban in Patients with Atrial Fibrillation
Among patients with atrial fibrillation at risk for stroke, treatment with asundexian at a dose of 50 mg once daily was associated with a higher incidence of stroke or systemic embolism than treatment with apixaban in the period before the trial was stopped prematurely. There were fewer major bleeding events with asundexian than with apixaban during this time. (Funded by Bayer; OCEANIC-AF ClinicalTrials.gov number, NCT05643573; EudraCT number, 2022-000758-28.).
Authors
- Isabelle C. Van Gelder (ORCID: https://orcid.org/0000-0002-7579-1201)
- W. Schuyler Jones (ORCID: https://orcid.org/0000-0002-7288-9596)
- Josephine Harrington (ORCID: https://orcid.org/0000-0001-5169-117X)
- Martin E W Hemels (ORCID: https://orcid.org/0000-0002-2373-9858)
- Manesh R. Patel (ORCID: https://orcid.org/0000-0002-2393-0855)
- Rosa Coppolecchia (ORCID: https://orcid.org/0000-0003-4652-8401)
- Jan Steffel (ORCID: https://orcid.org/0000-0002-1477-9153)
- Valeria Caso (ORCID: https://orcid.org/0000-0002-2020-8891)
- Jonathan Paul Piccini (ORCID: https://orcid.org/0000-0003-0772-2404)
- Hardi Mundl (ORCID: https://orcid.org/0000-0001-6218-3058)
- Christopher Hammett (ORCID: https://orcid.org/0000-0002-0931-9486)
- James Hung
- Gregory Y.H. Lip (ORCID: https://orcid.org/0000-0002-7566-1626)
- Masaharu Akao
- Diana A. Gorog (ORCID: https://orcid.org/0000-0002-9286-1451)
- Shaun G. Goodman (ORCID: https://orcid.org/0000-0001-8068-2440)
- Paulus Kirchhof (ORCID: https://orcid.org/0000-0002-1881-0197)
- Christoph Neumann (ORCID: https://orcid.org/0000-0001-8765-2068)
- Michiel Rienstra (ORCID: https://orcid.org/0000-0002-2581-070X)
- Renato D. Lópes (ORCID: https://orcid.org/0000-0003-2999-4961)
- Raffaele De Caterina (ORCID: https://orcid.org/0000-0003-1637-574X)
- John Hunter Alexander (ORCID: https://orcid.org/0000-0002-1444-2462)
- Thomas Viethen (ORCID: https://orcid.org/0000-0002-5334-1197)
- Keith C. Ferdinand (ORCID: https://orcid.org/0000-0003-3338-4410)
- Jonas Oldgren (ORCID: https://orcid.org/0000-0002-9969-3921)
- Frank W. Rockhold (ORCID: https://orcid.org/0000-0003-3732-4765)
- Andrea M. Russo (ORCID: https://orcid.org/0000-0002-3129-6161)
- Chang-Sheng Ma
- Stephen J. Ellis
Institutions
- Radboud University Nijmegen (NL)
- Duke University (US)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1056/nejmoa2407105
- Citations
- 125
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 50.25
Funders
- Bayer