Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ1−42 oligomers
Microglia are key mediators of both protection and neurodegeneration in response to Aβ. Polarizing microglia toward a protective state could be used as a preventative strategy against Aβ-induced neurotoxicity.
Authors
- Elizabeth McNair
- Jian Zou (ORCID: https://orcid.org/0000-0003-3511-8159)
- Angie L. Mordant (ORCID: https://orcid.org/0000-0002-0151-4498)
- Leon G. Coleman (ORCID: https://orcid.org/0000-0003-1693-3799)
- Laura E. Herring (ORCID: https://orcid.org/0000-0003-4496-7312)
- Scott P. Lyons (ORCID: https://orcid.org/0000-0002-3004-0148)
- Ryan P. Vetreno (ORCID: https://orcid.org/0000-0003-0449-395X)
- Sagan DeCastro
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1186/s12974-024-03208-2
- Citations
- 9
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.23
Funders
- Center for Alcohol Studies
- National Institutes of Health
- National Cancer Institute
- Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
- Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill