Therapeutic Effects of Heart Failure Medical Therapies on Standardized Kidney Outcomes: Comprehensive Individual Participant–Level Analysis of 6 Randomized Clinical Trials
When applying standardized stringent kidney end point definitions, steroidal mineralocorticoid receptor antagonists, angiotensin receptor-neprilysin inhibitor, and SGLT2 inhibitors have either neutral or beneficial effects on kidney outcomes in heart failure. Applying less stringent definitions increased event rates but included acute declines in eGFR that might not ultimately reflect long-term effects on kidney disease progression.
Authors
- Brian Lee Claggett (ORCID: https://orcid.org/0000-0002-4215-9218)
- Brendon Lange Neuen (ORCID: https://orcid.org/0000-0001-9276-8380)
- Pardeep S. Jhund (ORCID: https://orcid.org/0000-0003-4306-5317)
- John J.V. McMurray (ORCID: https://orcid.org/0000-0002-6317-3975)
- Marc A. Pfeffer (ORCID: https://orcid.org/0000-0003-3876-7568)
- Finnian R. McCausland
- Jawad H. Butt (ORCID: https://orcid.org/0000-0002-7380-4144)
- Faiez M. Zannad (ORCID: https://orcid.org/0000-0001-7456-1570)
- Iris E. Beldhuis (ORCID: https://orcid.org/0000-0002-3679-168X)
- Milton Packer (ORCID: https://orcid.org/0000-0003-1828-2387)
- Scott David Solomon (ORCID: https://orcid.org/0000-0003-3698-9597)
- Muthiah Vaduganathan (ORCID: https://orcid.org/0000-0003-0885-1953)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Akshay S. Desai (ORCID: https://orcid.org/0000-0002-1443-0701)
- Bertram Pitt
- Hiddo J.L. Heerspink
Institutions
- Brigham and Women's Hospital (US)
- University Medical Center Groningen (NL)
- Inserm (FR)
- University of Groningen (NL)
- University of Michigan (US)
- Baylor University Medical Center (US)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- UNSW Sydney (AU)
- British Heart Foundation (GB)
- Zealand University Hospital (DK)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- National University Heart Centre Singapore (SG)
- The George Institute for Global Health (AU)
- Université Bourgogne Franche-Comté (FR)
- Duke-NUS Medical School (SG)
- National Heart Centre Singapore (SG)
- French Clinical Research Infrastructure Network (FR)
- University of Glasgow (GB)
- Université de Lorraine (FR)
Publication Details
- Journal
- Circulation
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1161/circulationaha.124.071110
- Citations
- 13
- Primary Topic
- Heart Failure Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.23