Optimal treatment for women with acute hypertension in pregnancy; a randomized trial comparing intravenous labetalol versus nicardipine
In our prematurely halted small RCT, we were unable to provide evidence for the optimal choice of treatment for severe hypertension to improve neonatal outcome and/or to obtain faster blood pressure control. Differences in Respiratory distress syndrome and neonatal hypoglycemia between the groups might be the result of coincidental finding due to the small groups included in the study. A larger randomized trial would be needed to determine the safest and most efficacious (intravenous) therapy for severe hypertension in pregnancy. This study emphasizes the challenges of conducting a RCT for the optimal treatment for these women.
Authors
- Wessel Ganzevoort (ORCID: https://orcid.org/0000-0002-7243-2115)
- Marjon A. de Boer (ORCID: https://orcid.org/0000-0002-9386-649X)
- Benjamin Gravesteijn
- Christianne J.M. de Groot (ORCID: https://orcid.org/0000-0003-3277-2542)
- Jeske M. bij de Weg (ORCID: https://orcid.org/0000-0002-9275-8825)
- Ben W. Mol (ORCID: https://orcid.org/0000-0001-8337-550X)
- Frank van Bel
- Wietske Hermes
Institutions
- University Medical Center Utrecht (NL)
- Medisch Centrum Haaglanden (NL)
- GGD Amsterdam (NL)
- Amsterdam University Medical Centers (NL)
- Monash University (AU)
- University of Amsterdam (NL)
Publication Details
- Journal
- Pregnancy Hypertension
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.preghy.2024.101153
- Citations
- 2
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Haaglanden Medisch Centrum