Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma
Our study revealed the central role of the miR-107/KIF23 axis in controlling tumor cell fitness and hepatocellular carcinoma progression. The results demonstrate that the overexpression of miR-107 or silencing of its target, KIF23, markedly suppresses the proliferation, survival, and motility of human and mouse hepatoma cells. In this work, we demonstrate that the disruption of miR-107/Kif23 signaling effectively protects mice from an aggressive form of oncogene-induced liver cancer in vivo, implying that targeting miR-107/KIF23 might be a novel therapeutic approach for hepatocellular carcinoma in humans.
Authors
- Tom Luedde (ORCID: https://orcid.org/0000-0002-6288-8821)
- Lara R. Heij (ORCID: https://orcid.org/0000-0002-0602-3356)
- Mathias Heikenwälder (ORCID: https://orcid.org/0000-0002-3135-2274)
- Johannes G. Bode (ORCID: https://orcid.org/0000-0002-7141-0694)
- Sanchari Roy (ORCID: https://orcid.org/0000-0001-5457-6644)
- Ahmed Ghallab (ORCID: https://orcid.org/0000-0003-0695-3403)
- Jan Georg Hengstler (ORCID: https://orcid.org/0000-0002-1427-5246)
- Thomas Longerich (ORCID: https://orcid.org/0000-0001-8888-1030)
- Wiebke Albrecht (ORCID: https://orcid.org/0000-0002-5498-8507)
- Lars Zender (ORCID: https://orcid.org/0000-0001-7626-2849)
- Matthias A. Dille
- Rossella Pellegrino (ORCID: https://orcid.org/0000-0001-9473-0482)
- M. Castoldi (ORCID: https://orcid.org/0000-0003-2484-936X)
- Stephanie D. Wolf (ORCID: https://orcid.org/0000-0003-2693-1260)
- Mihael Vucur (ORCID: https://orcid.org/0000-0003-4078-1668)
- Wolfram Trudo Knoefel (ORCID: https://orcid.org/0000-0003-2472-8314)
- Ulf P. Neumann (ORCID: https://orcid.org/0000-0002-3831-8917)
- Veronika Buettner
- Carolin Angendohr
- Christoph Roderburg (ORCID: https://orcid.org/0000-0002-2245-6362)
- Michael T. Singer
- Georg Flügen
Institutions
- German Cancer Research Center (DE)
- South Valley University (EG)
- TU Dortmund University (DE)
- Heidelberg University (DE)
- Erasmus MC (NL)
- University Hospital Heidelberg (DE)
- Düsseldorf University Hospital (DE)
- Essen University Hospital (DE)
- University Children's Hospital Tübingen (DE)
- Leibniz Research Centre for Working Environment and Human Factors (DE)
- Heinrich Heine University Düsseldorf (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Journal of Hepatology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.jhep.2024.08.025
- Citations
- 6
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Gesundheit
- Deutsche Krebshilfe
- Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen
- H2020 European Research Council