AST-120 alleviates renal ischemia-reperfusion injury by inhibiting HK2-mediated glycolysis
In conclusion, AST-120 alleviates renal IRI via suppressing HK2-mediated glycolysis, which suppresses H3K18 lactylation and further reduces HK2 levels. This study proposes a novel mechanism by which AST-120 alleviates IRI.
Authors
- Haijin Gao
- Feng Xu (ORCID: https://orcid.org/0000-0002-9642-6406)
- Jinmeng Zhou
- Lei Wang (ORCID: https://orcid.org/0000-0001-9695-3196)
- Jinbao Zhang (ORCID: https://orcid.org/0000-0002-5688-5261)
- Yutong Zhao
- Ke Li
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1186/s10020-024-00902-y
- Citations
- 19
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 6.44