Effect of Sumatriptan in an Adult with Meningitis-Induced Severe Headache: a Case Report

Abstract Meningitis is a serious neurological condition caused by inflammation of the meninges due to infection. Meningitis typically triggers symptoms of severe headaches, high fever, and neck stiffness. In this case, we evaluate the effect of sumatriptan on meningitis-induced severe headache and the underlying pathophysiology. In this case report, we present a patient with no history of migraine with a meningitis-induced headache. The patient did not experience analgesic relief from paracetamol, ibuprofen, or tramadol, but significant relief was achieved after the administration of sumatriptan. While treating his headache, diagnostic interventions such as lumbar puncture were done, and PCR analysis of the cerebrospinal fluid identified varicella-zoster virus. The patient experienced a significant analgesic effect from sumatriptan, possibly due to constriction of the meningeal arteries, blocking of meningeal inflammation, or both.