The deubiquitinase USP44 enhances cisplatin chemosensitivity through stabilizing STUB1 to promote LRPPRC degradation in neuroblastoma
Our findings demonstrate that the USP44-STUB1-LRPPRC axis plays a pivotal role in neuroblastoma chemoresistance and provides potential targets for neuroblastoma therapy and prognostication.
Authors
- Le Li (ORCID: https://orcid.org/0000-0002-3665-1193)
- Xun-Hua Zhu
- Liang-Jun Qin
- Ruizhong Zhang
- Kai Chen (ORCID: https://orcid.org/0000-0002-8647-1182)
- Yilin Li (ORCID: https://orcid.org/0000-0001-9216-4093)
- Haiyun Wang (ORCID: https://orcid.org/0000-0002-1385-0827)
- Hui Xu (ORCID: https://orcid.org/0000-0002-7989-6932)
- Shiwei He (ORCID: https://orcid.org/0000-0002-1590-0656)
- Liang Zeng (ORCID: https://orcid.org/0000-0002-4755-775X)
- Ying-Qing Li
- Na Liu (ORCID: https://orcid.org/0000-0003-0949-4046)
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Sun Yat-sen University Cancer Center (CN)
- University of South China (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1093/neuonc/noae175
- Citations
- 10
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.69