Approach to the Paediatric Patient With Suspected Pheochromocytoma or Paraganglioma Versus Neuroblastoma
Catecholamine-producing tumors of childhood include neuroblastic tumors, phaeochromocytoma, and paraganglioma (PPGL). PPGL and neuroblastic tumors can arise in similar anatomical locations and clinical presentations can overlap, resulting in diagnostic challenges. Distinguishing between these tumor types is critical as management and long-term surveillance strategies differ depending on the diagnosis. Herein we describe 2 clinical cases and illustrate key considerations in the diagnostic workup of a neuroblastoma vs PPGL for patients presenting with adrenal, pelvic, and retroperitoneal masses in childhood.
Authors
- Inês Harper
- Christina Pamporaki (ORCID: https://orcid.org/0000-0003-0772-1604)
- Emile Hendriks (ORCID: https://orcid.org/0000-0002-0795-1832)
- Ben J. Fleming (ORCID: https://orcid.org/0000-0003-0111-8679)
- Elizabeth Hook
- Ruth Therese Casey (ORCID: https://orcid.org/0000-0003-4058-3135)
- Graeme Eisenhofer (ORCID: https://orcid.org/0000-0002-8601-9903)
- Matthew Jonathan Murray (ORCID: https://orcid.org/0000-0002-4480-1147)
- C. Delisle Burns
- Ruth Armstrong (ORCID: https://orcid.org/0000-0002-7958-2829)
Institutions
- University of Cambridge (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Bridge University (SS)
- University Hospital Carl Gustav Carus (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1210/clinem/dgae603
- Citations
- 1
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Institute for Health and Care Research
- NIHR Cambridge Biomedical Research Centre