Insilico Simulation Studies for Tuberculosis Drug Discovery and its Response

From high treatment and with such precaution measures TB (Tuberculosis) came with leading cause of deaths in the world. For Tuberculosis it increasing drug resistance for different kind of TB like Multidrug-resistant TB and Extensively drug-resistant TB, increasing relapse and in efficiency of drug for TB pathogen.it take longer duration, it affect on human body with infection from HIV and other autoimmune disorder have pushed it to a lethal level and for this we need more effective drugs. With the help of CADD technology we can findout more viable drug molecules for the better treatment of Mycobacterium tuberculosis .Insilico drug design is a more efficient ,time saving and cost effective process. With the help of inslico drug design we can identify/Generate lead molecules that can inhibit the activity of TB. In inslico process we took 4GZR protein which is Crystal structure of the Mycobacterium tuberculosis and lead(ligand) with the support of computer aided drug design (CADD) pipeline and bioinformatics software tools. Key words: Tuberculosis, Insilico Drug Design, Computer Aided Drug Design (CADD), Bioinformatics Tool and Technology.