Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial homeostasis
The study confirms the pivotal function of PNPT1 in the development of MAFLD through its interactions with Mcl-1 and its regulatory effects on lipid metabolism and mitochondrial stability. These insights highlight the intricate association between PNPT1 and MAFLD, shedding light on its molecular pathways and presenting a potential new therapeutic avenue for MAFLD management.
Authors
- Wujiang Shi (ORCID: https://orcid.org/0009-0009-2491-787X)
- Xinlei Zou
- Jianjun Gao (ORCID: https://orcid.org/0000-0001-6138-4472)
- Zhaoqiang Xu
- Yifei Ge
- Xiangyu Zhong
- Canghai Guan (ORCID: https://orcid.org/0000-0002-6439-1851)
- Shaowu Bi
- Chengru Yang
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.molmet.2024.102022
- Citations
- 6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.32
Funders
- Heilongjiang Postdoctoral Science Foundation
- National Natural Science Foundation of China
- Heilongjiang Provincial Postdoctoral Science Foundation