Single-cell RNA sequencing reveals intratumoral heterogeneity and multicellular community in primary hepatocellular carcinoma underlying microvascular invasion
We provide a comprehensive single-cell atlas of HCC patients with MVI, shedding light on the immunosuppressive ecosystem and upregulated signaling associated with MVI. These findings demonstrate that intercellular mechanisms drive MVI and provide a potential immunotherapeutic target for HCC patients with HCC and underlying MVI.
Authors
- Biao Gao
- Xiaohui Sun (ORCID: https://orcid.org/0000-0001-6972-9009)
- X. H. Li (ORCID: https://orcid.org/0000-0002-3155-9988)
- Tianyu Jiao
- Lai Song
- Zishan Zhou
- Zizhong Yang (ORCID: https://orcid.org/0000-0002-2143-8226)
- Shun-chang Jiao (ORCID: https://orcid.org/0000-0001-8017-5342)
- Junfeng Li (ORCID: https://orcid.org/0000-0001-9313-6975)
- Biying Wang (ORCID: https://orcid.org/0000-0002-7527-962X)
- Xiao Ling Zhao (ORCID: https://orcid.org/0000-0003-4825-7422)
- Shichun Lu (ORCID: https://orcid.org/0000-0002-1748-1360)
- Yang Yu (ORCID: https://orcid.org/0000-0003-2602-6041)
- Zhuoya Sun
- Hao Jiang (ORCID: https://orcid.org/0000-0003-1198-8643)
Institutions
- Nankai University (CN)
- Sinovac Biotech (CN)
- Chinese PLA General Hospital (CN)
- Beijing Biocytogen (China) (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37233
- Citations
- 4
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 1.14