Randomised Trial of No, Short-term, or Long-term Androgen Deprivation Therapy with Postoperative Radiotherapy After Radical Prostatectomy: Results from the Three-way Comparison of RADICALS-HD (NCT00541047)
Long-term outcomes after radical prostatectomy are usually favourable. In those indicated for postoperative RT and considered suitable for no, short-term, or long-term ADT, there was no evidence of improvement with addition of ADT. Future research should focus on patients at a higher risk of metastases in whom improvements are required more urgently.
Authors
- Charles Catton (ORCID: https://orcid.org/0000-0003-2248-1370)
- Raj Persad (ORCID: https://orcid.org/0000-0002-9121-0550)
- Mahesh Parmar (ORCID: https://orcid.org/0000-0003-0166-1700)
- Adrian David Cook (ORCID: https://orcid.org/0000-0003-4417-2632)
- Heather Payne (ORCID: https://orcid.org/0000-0003-3238-5040)
- William Cross (ORCID: https://orcid.org/0000-0001-9276-3053)
- Claire Amos
- René Horsleben Petersen (ORCID: https://orcid.org/0000-0002-3586-1869)
- Fred Saad (ORCID: https://orcid.org/0000-0003-2986-5617)
- Matthew R. Sydes (ORCID: https://orcid.org/0000-0002-9323-1371)
- Wendy R. Parulekar (ORCID: https://orcid.org/0000-0002-6007-7494)
- Noel W. Clarke (ORCID: https://orcid.org/0000-0001-7776-8059)
- Jane Worlding
- Rakesh Raman (ORCID: https://orcid.org/0000-0003-0159-7227)
- Ian Sayers (ORCID: https://orcid.org/0000-0002-7685-178X)
- Howard Kynaston (ORCID: https://orcid.org/0000-0003-1902-9930)
- Chris Parker (ORCID: https://orcid.org/0000-0001-6512-124X)
- John Logue (ORCID: https://orcid.org/0000-0002-5900-0676)
- L. Bower
Institutions
- University of Copenhagen (DK)
- Royal Marsden NHS Foundation Trust (GB)
- University Health Network (CA)
- Institute of Cancer Research (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Queen's University (CA)
- New Cross Hospital (GB)
- St James's University Hospital (GB)
- At Bristol (GB)
- Princess Margaret Cancer Centre (CA)
- University Hospitals Coventry and Warwickshire NHS Trust (GB)
- Rigshospitalet (DK)
- University of Manchester (GB)
- MRC Clinical Trials Unit at UCL (GB)
- Salford Royal Hospital (GB)
- Kent and Canterbury Hospital (GB)
- The Christie Hospital (GB)
- Centre Hospitalier de l’Université de Montréal (CA)
- The Prostate Centre (GB)
- University College London (GB)
- Cardiff University (GB)
Publication Details
- Journal
- European Urology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.eururo.2024.07.026
- Citations
- 27
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 11.31
Funders
- Royal Marsden NHS Foundation Trust
- UK Research and Innovation
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Cancer Research UK
- National Institute for Health and Care Research
- Canadian Cancer Society
- University College London
- Medical Research Council