CircZNF609/miR-324-5p/voltage-dependent anion channel 1 axis promotes malignant progression of ovarian cancer cells

The dysregulation of circular RNAs (circRNAs) has been associated with OC development and progression. This study investigated the role of circZNF609 in ovarian cancer (OC) by analyzing its impact on cell proliferation, migration, and invasion. Initially, the study assessed the expression of circZNF609 in OC tissues and adjacent normal tissues. The results revealed elevated circZNF609 levels in OC tissues and cell lines, correlating with poor prognosis, lymph node metastasis, and advanced clinical stage. Subsequently, <i>in vitro</i> and <i>in vivo</i> experiments were conducted to elucidate the biological functions of circZNF609 in OC progression. The findings showed that the knockdown of circZNF609 resulted in reduced OC cell proliferation, migration, invasion, and tumor growth. Mechanistically, circZNF609 was identified to function as a sponge for miR-324-5p, thereby upregulating voltage-dependent anion channel 1 (VDAC1) expression and promoting OC progression. Our findings indicate that circZNF609 promotes OC via the miR-324-5p/VDAC1 axis, contributing to the therapeutic targeting of this disease.