Inhibition of CTLA-4 accelerates atherosclerosis in hyperlipidemic mice by modulating the Th1/Th2 balance via the NF-κB signaling pathway
Anti-CTLA-4 treatment promotes the progression of atherosclerosis by activating NF-κB signaling and modulating the Th1/Th2 balance. Our results provide a rationale for preventing and/or treating atherosclerosis accelerated by anti-CTLA-4 antibody therapy in cancer patients.
Authors
- Weiwei Jiang (ORCID: https://orcid.org/0000-0002-1500-9759)
- Liang Chen (ORCID: https://orcid.org/0000-0001-6644-477X)
- Zi Hong
- M. Zhao
- An‐Qi Shang
- Changjiang Yu (ORCID: https://orcid.org/0000-0001-6395-5814)
- Zhi‐Ren Zhang (ORCID: https://orcid.org/0000-0003-1324-6934)
- Di Zhu
- Hong Guan
- Mei Zhang (ORCID: https://orcid.org/0000-0003-2717-7167)
Institutions
- Harbin Medical University (CN)
- Heilongjiang Academy of Sciences (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e37278
- Citations
- 3
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China
- Science and Technology Department, Heilongjiang Province