CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells
We found that hTICs can be targeted and induced into a senescent state during the pre-HCC stage. The SASP factors released by senescent hTICs further activate the immune response, facilitating the clearance of hTICs, and consequently suppressing HCC occurrence. We highlight the importance of pre-HCC interventions and propose that senescence-inducing drugs hold promise for preventing HCC initiation under CLI.
Authors
- Changcheng Liu (ORCID: https://orcid.org/0000-0001-7922-7950)
- Huiru Yang (ORCID: https://orcid.org/0000-0002-2886-8499)
- Mingyang Xu (ORCID: https://orcid.org/0009-0006-0199-9815)
- Weizhi He (ORCID: https://orcid.org/0000-0001-6869-4983)
- Yongchao Cai
- Zhiying He (ORCID: https://orcid.org/0000-0002-0087-2277)
- Xiuhua Li (ORCID: https://orcid.org/0000-0002-2601-4780)
- Chong Li (ORCID: https://orcid.org/0000-0002-9215-6779)
- Miaomiao Chen (ORCID: https://orcid.org/0009-0008-1493-656X)
- Hongyu Xu (ORCID: https://orcid.org/0009-0004-4511-6186)
- Guoxiu Wu
- Wenjian Chen (ORCID: https://orcid.org/0000-0003-1310-8611)
- Wencheng Zhang (ORCID: https://orcid.org/0000-0003-2848-1611)
- Shiwen Sun
- Yanli Lu
- Dong Jiang (ORCID: https://orcid.org/0000-0002-2001-144X)
Institutions
- Shanghai East Hospital (CN)
- Shanghai Cell Therapy Research Institute (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.jare.2024.08.034
- Citations
- 12
- Primary Topic
- Advanced Breast Cancer Therapies
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality
- Tongji University