Retinal Toxicity Secondary to Suprachoroidal Migration of Mitomycin-C

<b>Purpose:</b> To report a case of suprachoroidal migration of mitomycin-C (MMC) with ensuing retinal toxicity after trabeculectomy. <b>Methods:</b> A case report of retinal toxicity is described with multimodal imaging. <b>Results:</b> A patient developed occlusion of the retinal and choroidal vasculature in a segmental fashion that could be explained by suprachoroidal diffusion. Fundus autofluorescence showed a stippled pattern over an area of hypofluorescence in the superonasal quadrant, and a late fluorescein angiogram image showed staining of the superonasal quadrant with dependent leakage toward the optic nerve and macula. <b>Conclusions:</b> MMC is commonly used in glaucoma-filtering surgical procedures, and few cases of postoperative posterior segment toxicity have been reported. To our knowledge, we are the first to describe suprachoroidal migration of MMC with subsequent retinal toxicity.

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Publication Details

Journal
Journal of VitreoRetinal Diseases
Published
2024-08-31
DOI
https://doi.org/10.1177/24741264241269533
Citations
1
Primary Topic
Glaucoma and retinal disorders
Type
article
Field-Weighted Citation Impact
0.54
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article

Retinal Toxicity Secondary to Suprachoroidal Migration of Mitomycin-C

Karim Dirani, Pradeepa Yoganathan, Faisal Ridha Al-Timimi, Daniel Juzych et al.
1 citations
Journal of VitreoRetinal Diseases
Glaucoma and retinal disorders
0.54
article

Retinal Toxicity Secondary to Suprachoroidal Migration of Mitomycin-C

Karim Dirani, Pradeepa Yoganathan, Faisal Ridha Al-Timimi, Daniel Juzych, Cesar Alfaro
article en
1 citations

Abstract

<b>Purpose:</b> To report a case of suprachoroidal migration of mitomycin-C (MMC) with ensuing retinal toxicity after trabeculectomy. <b>Methods:</b> A case report of retinal toxicity is described with multimodal imaging. <b>Results:</b> A patient developed occlusion of the retinal and choroidal vasculature in a segmental fashion that could be explained by suprachoroidal diffusion. Fundus autofluorescence showed a stippled pattern over an area of hypofluorescence in the superonasal quadrant, and a late fluorescein angiogram image showed staining of the superonasal quadrant with dependent leakage toward the optic nerve and macula. <b>Conclusions:</b> MMC is commonly used in glaucoma-filtering surgical procedures, and few cases of postoperative posterior segment toxicity have been reported. To our knowledge, we are the first to describe suprachoroidal migration of MMC with subsequent retinal toxicity.

Journal of VitreoRetinal DiseasesVol. 8(6)
University of Toronto (CA), Kresge Eye Institute (US), University of Windsor (CA)
Openalex Percentile: Top 33%
Glaucoma and retinal disorders
0.54
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Retinal Toxicity Secondary to Suprachoroidal Migration of Mitomycin-C — Karim Dirani, Pradeepa Yoganathan, et al. · Journal of VitreoRetinal Diseases (2024) | TGRS Research Map | TGRS