Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations
Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.
Authors
- Alexi Runnels (ORCID: https://orcid.org/0000-0002-8592-1444)
- Adriana O. Mitchell
- Dennis W. Dickson (ORCID: https://orcid.org/0000-0001-7189-7917)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- David Alan Bennett (ORCID: https://orcid.org/0000-0003-3689-554X)
- Merve Atık
- Joseph S. Reddy (ORCID: https://orcid.org/0000-0002-1783-4453)
- Abby Vander Linden (ORCID: https://orcid.org/0000-0003-1932-2483)
- Harrison Xiao
- Nicholas T. Seyfried (ORCID: https://orcid.org/0000-0002-4507-624X)
- Allan I. Levey (ORCID: https://orcid.org/0000-0002-3153-502X)
- David X. Márquez (ORCID: https://orcid.org/0000-0001-8903-4941)
- Lisa L. Barnes (ORCID: https://orcid.org/0000-0002-0072-9817)
- Erming Wang (ORCID: https://orcid.org/0009-0000-8056-0785)
- Hasini Reddy
- Jo Scanlan
- Erica Modeste (ORCID: https://orcid.org/0000-0002-2072-129X)
- Charlotte C.G. Ho (ORCID: https://orcid.org/0000-0002-9135-1652)
- Philip L. De Jager (ORCID: https://orcid.org/0000-0002-8057-2505)
- Geidy E. Serrano (ORCID: https://orcid.org/0000-0002-9527-2011)
- Kátia de Paiva Lopes (ORCID: https://orcid.org/0000-0002-0240-0126)
- Eric B. Dammer (ORCID: https://orcid.org/0000-0003-2947-7606)
- Anna K. Greenwood (ORCID: https://orcid.org/0000-0001-9351-7815)
- Minerva M. Carrasquillo (ORCID: https://orcid.org/0000-0002-3231-9134)
- Fatemeh Seifar (ORCID: https://orcid.org/0000-0003-0387-6991)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Marla Gearing (ORCID: https://orcid.org/0000-0002-1959-7412)
- Luming Yin
- Andrew F. Teich (ORCID: https://orcid.org/0000-0002-1916-8490)
- Thomas G. Beach (ORCID: https://orcid.org/0000-0003-3296-6128)
- William L. Poehlman (ORCID: https://orcid.org/0000-0002-3659-9663)
- Laura Heath (ORCID: https://orcid.org/0000-0002-0318-2773)
- Anantharaman Shantaraman (ORCID: https://orcid.org/0000-0003-1384-941X)
- Lingyan Ping (ORCID: https://orcid.org/0000-0002-2623-5145)
- Nilüfer Ertekin‐Taner (ORCID: https://orcid.org/0000-0003-4436-8889)
- Richard P Mayeux (ORCID: https://orcid.org/0000-0001-6519-9696)
- Stephanie R. Oatman
- James J. Lah (ORCID: https://orcid.org/0000-0002-8810-620X)
- Mariet Allen (ORCID: https://orcid.org/0000-0002-2685-427X)
- Zachary Quicksall (ORCID: https://orcid.org/0000-0002-8791-0925)
- Stefan Prokop (ORCID: https://orcid.org/0000-0002-5633-2149)
- Aliza P. Wingo (ORCID: https://orcid.org/0000-0002-6360-6726)
- Geovanna Yepez
- Bin Zhang (ORCID: https://orcid.org/0000-0002-9549-5653)
- Xianfeng Chen (ORCID: https://orcid.org/0000-0002-7531-5862)
- Edward J. Fox
- Yiyi Ma (ORCID: https://orcid.org/0000-0002-3609-8877)
- Duc M. Duong (ORCID: https://orcid.org/0000-0002-3325-9233)
- Thuy Nguyen (ORCID: https://orcid.org/0000-0001-8879-7090)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Kaiming Xu
- V. Haroutunian
- Yanling Wang (ORCID: https://orcid.org/0009-0003-0061-9946)
Institutions
- Rush University Medical Center (US)
- Sage Bionetworks (US)
- Emory University (US)
- Columbia University Irving Medical Center (US)
- Jacksonville College (US)
- University of Florida (US)
- University of Illinois Chicago (US)
- Institute for Neurodegenerative Disorders (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- New York Genome Center (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1002/alz.14208
- Citations
- 20
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.53
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Alzheimer's Association
- University of Pennsylvania
- Mayo Foundation for Medical Education and Research
- Arizona Department of Health Services
- CurePSP
- Arizona Biomedical Research Commission
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke