Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations

Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2024-08-30
DOI
https://doi.org/10.1002/alz.14208
Citations
20
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
6.53

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Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations

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Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations

Alexi Runnels, Adriana O. Mitchell, Dennis W. Dickson, Sudha S. Seshadri, David Alan Bennett, Merve Atık, Joseph S. Reddy, Abby Vander Linden, Harrison Xiao, Nicholas T. Seyfried, Allan I. Levey, David X. Márquez, Lisa L. Barnes, Erming Wang, Hasini Reddy, Jo Scanlan, Erica Modeste, Charlotte C.G. Ho, Philip L. De Jager, Geidy E. Serrano, Kátia de Paiva Lopes, Eric B. Dammer, Anna K. Greenwood, Minerva M. Carrasquillo, Fatemeh Seifar, Edward B. Lee, Marla Gearing, Luming Yin, Andrew F. Teich, Thomas G. Beach, William L. Poehlman, Laura Heath, Anantharaman Shantaraman, Lingyan Ping, Nilüfer Ertekin‐Taner, Richard P Mayeux, Stephanie R. Oatman, James J. Lah, Mariet Allen, Zachary Quicksall, Stefan Prokop, Aliza P. Wingo, Geovanna Yepez, Bin Zhang, Xianfeng Chen, Edward J. Fox, Yiyi Ma, Duc M. Duong, Thuy Nguyen, Thomas S. Wingo, Kaiming Xu, V. Haroutunian, Yanling Wang
article en
20 citations

Abstract

Accelerating Medicines Partnership in Alzheimer's Disease Diversity Initiative led brain tissue profiling in multi-ethnic populations. Brain multi-omics data is generated from Black American, Latin American, and non-Hispanic White donors. RNA, whole genome sequencing and tandem mass tag proteomicsis completed and shared. Multiple brain regions including caudate, temporal and dorsolateral prefrontal cortex were profiled.

Alzheimer s & DementiaVol. 20(10)
Rush University Medical Center (US), Sage Bionetworks (US), Emory University (US), Columbia University Irving Medical Center (US), Jacksonville College (US), University of Florida (US), University of Illinois Chicago (US), Institute for Neurodegenerative Disorders (US), Banner Sun Health Research Institute (US), Mayo Clinic in Florida (US), New York Genome Center (US), University of Pennsylvania (US), Icahn School of Medicine at Mount Sinai (US)
Michael J. Fox Foundation for Parkinson's Research, Alzheimer's Association, University of Pennsylvania, Mayo Foundation for Medical Education and Research, Arizona Department of Health Services, CurePSP, Arizona Biomedical Research Commission, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Partnerships for the goals
Openalex Percentile: Top 3%
Alzheimer's disease research and treatments
6.53
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