Dehydrocorydaline attenuates myocardial ischemia-reperfusion injury via the FoXO signalling pathway: A multimodal study based on network pharmacology, molecular docking, and experimental study
By upregulating the FoxO signaling pathway to inhibit apoptosis, DHC exerts a cardioprotective effect, which could serve as a potential therapeutic option for MIRI.
Authors
- Daxin Chen (ORCID: https://orcid.org/0000-0001-7028-0704)
- Zikai Yu (ORCID: https://orcid.org/0000-0001-9377-9196)
- Guosheng Lin (ORCID: https://orcid.org/0000-0002-0329-7458)
- Yingdong Lu (ORCID: https://orcid.org/0000-0003-4369-4084)
- Wenwen Yang (ORCID: https://orcid.org/0000-0001-6385-1089)
- Hongzheng Li (ORCID: https://orcid.org/0000-0002-3459-9539)
- Meizhu Wu (ORCID: https://orcid.org/0000-0003-2010-8644)
- Changgeng Fu (ORCID: https://orcid.org/0000-0003-3258-6360)
- Aling Shen (ORCID: https://orcid.org/0000-0002-5081-3523)
- Zhi Guo
- Zucheng Shang
- Mengfan Li (ORCID: https://orcid.org/0009-0003-4814-5583)
- Keji Chen (ORCID: https://orcid.org/0000-0003-4621-6539)
- Renfeng Li (ORCID: https://orcid.org/0000-0002-8104-4608)
- Hua Qu (ORCID: https://orcid.org/0000-0001-5079-1291)
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Xiyuan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.jep.2024.118738
- Citations
- 14
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 5.06
Funders
- National Natural Science Foundation of China