<i>Haemophilus influenzae</i> Endophthalmitis Associated With Intravitreal Pegcetacoplan Injection

<b>Purpose:</b> To describe a case of endophthalmitis caused by <i>Haemophilus influenzae</i>, an encapsulated bacterium, after intravitreal (IVT) injection of pegcetacoplan. <b>Methods:</b> A single retrospective case was evaluated. <b>Results:</b> An 88-year-old woman with a history of diabetes mellitus, on dialysis for chronic kidney disease, hypertension, hypothyroidism, diffuse large B-cell lymphoma, and geographic atrophy in both eyes received an IVT injection of pegcetacoplan in both eyes. She subsequently developed endophthalmitis in the right eye caused by <i>H influenzae.</i> Further bloodwork showed <i>Proteus mirabilis</i> bacteremia. <b>Conclusions:</b> Pegcetacoplan, a complement inhibitor, may be associated with intraocular infections with encapsulated organisms, especially in immunocompromised patients.