V1bR enhances glucose-stimulated insulin secretion by paracrine production of glucagon which activates GLP-1 receptor
Our study revealed a crosstalk between α and β cells initiated by AVP/V1bR and mediated by glucagon/GLP-1R, providing a mechanism to develop new glucose-controlling therapies targeting V1bR.
Authors
- Yun Ying (ORCID: https://orcid.org/0000-0003-2306-0949)
- Xin Xie (ORCID: https://orcid.org/0000-0003-2314-4800)
- Shimeng Guo (ORCID: https://orcid.org/0000-0002-8086-5092)
Institutions
- Shanghai Institute of Materia Medica (CN)
- National Center for Drug Screening (CN)
- Drug Discovery Laboratory (Norway) (NO)
- Institute for Advanced Study (DE)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1186/s13578-024-01288-4
- Citations
- 4
- Primary Topic
- Electrolyte and hormonal disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- National Natural Science Foundation of China