<scp>RAN</scp> Translation of C9orf72‐Related Dipeptide Repeat Proteins in Zebrafish Recapitulates Hallmarks of Amyotrophic Lateral Sclerosis and Identifies Hypothermia as a Therapeutic Strategy
The transgenic model detailed in this paper provides a medium throughput in vivo research tool to further investigate the role of RAN-translation in C9orf72-ALS/FTD and further understand the mechanisms that underpin neuroprotective strategies. Hypothermic-TTM presents a viable therapeutic avenue to explore in the context of C9orf72-ALS/FTD. ANN NEUROL 2024;96:1058-1069.
Authors
- Lydia M. Castelli (ORCID: https://orcid.org/0000-0003-3620-4219)
- Alexander McGown (ORCID: https://orcid.org/0000-0002-3213-1895)
- Guillaume M. Hautbergue (ORCID: https://orcid.org/0000-0002-1621-261X)
- Olfat Abduljabbar
- David Burrows (ORCID: https://orcid.org/0000-0002-5833-9379)
- Pamela J. Shaw (ORCID: https://orcid.org/0000-0002-8925-2567)
- Tennore Ramesh (ORCID: https://orcid.org/0000-0001-8398-5367)
Institutions
- University of Sheffield (GB)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1002/ana.27068
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- Motor Neurone Disease Association
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council