Impact of Chronic Kidney Disease on Left Ventricular and Left Atrial Deformation in Patients with Anterior Myocardial Infarction as Detected by 2D -Speckle Tracking

Background: Chronic kidney disease (CKD) and coronary artery disease (CAD) represent major causes of morbidity and mortality worldwide. The aim of the current study is to investigate the value of 2D-STE in assessing the abnormalities in LV and LA function after anterior MI in patients with and without CKD.Methods: This prospective, single-center cohort study was conducted on 200 patients aged more than 18 years diagnosed with anterior wall myocardial infarction who were admitted to the coronary care unit at Benha University Hospital in the duration from February 2023 to January 2024. The study included 100 consecutive cases of anterior STEMI and mild to moderate (stages 2-3) CKD and were compared to 100 age and sex-matched cases of anterior STEMI with normal GFR (≥90ml/min/1.73m2).Results: Regarding the echocardiographic findings, EF, LV-GLS, LASr, LAScd, LASct, and TAPSE were significantly lower in patients with CKD (P