Microglia LILRB4 upregulation reduces brain damage after acute ischemic stroke by limiting CD8+ T cell recruitment
LILRB4 in microglia plays a crucial role in modulating the post-stroke immune response by regulating CD8<sup>+</sup> T cell infiltration and activation. Knockout of LILRB4 exacerbates ischemic brain injury by promoting CD8<sup>+</sup> T cell recruitment. Overexpression of LILRB4, conversely, offers neuroprotection. These findings highlight the therapeutic potential of targeting LILRB4 and its downstream pathways to mitigate immune-mediated damage in ischemic stroke.
Authors
- Jieli Chen (ORCID: https://orcid.org/0000-0001-5446-9101)
- Jialing Wu (ORCID: https://orcid.org/0000-0002-7923-1930)
- Lin Chen (ORCID: https://orcid.org/0000-0001-8530-2363)
- Kai Zheng (ORCID: https://orcid.org/0000-0002-3488-4946)
- Ying Cai (ORCID: https://orcid.org/0000-0003-4105-5916)
- Tao Chen
- Xiuhua Yao
- Yilin Ma
- Chengcheng Zhao (ORCID: https://orcid.org/0000-0002-8841-5424)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-7786-0231)
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Huanhu Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1186/s12974-024-03206-4
- Citations
- 27
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 6.68
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City