Optimization of the formulation of Tubiechong gel plaster and its effect on fracture healing by promoting angiogenesis in a rat model
The optimal dose of azone for TGP is 2 %. The transdermal penetration equation for this plaster is consistent with the Ritger-Peppas equation. The prepared plaster was stable for at least 3 months. X-ray images showed that the fracture healing was promoted by TGP in a dose-related form at all periods. Serum BALP, OC, CTX-I, and VEGF levels also indicated better fracture healing after treatment. TGP significantly stimulated angiogenesis and bone growth at the fracture site on days 7,14 and 21, and the effect of promoting bone growth was shown on the third day. These data prove that the prepared Tubiechong gel plasters can promote fracture healing by promoting angiogenesis.
Authors
- Zefeng Zhang (ORCID: https://orcid.org/0000-0002-1056-0824)
- Chun-Mei Wang
- Binghao Shao
- Yibo Wang (ORCID: https://orcid.org/0000-0003-2302-5684)
- Xing Chen (ORCID: https://orcid.org/0000-0001-9042-4568)
- Wei Xue (ORCID: https://orcid.org/0000-0003-0124-9433)
- Yuying Deng (ORCID: https://orcid.org/0000-0003-1234-7434)
- Xue-Qing Xie
- Jing Wang (ORCID: https://orcid.org/0000-0002-3793-3264)
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Traditional and Complementary Medicine
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.jtcme.2024.08.009
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Beijing University of Chinese Medicine
- National University's Basic Research Foundation of China
- Fundamental Research Funds for the Central Universities