Cognitive outcomes after fetal exposure to carbamazepine, lamotrigine, valproate or levetiracetam monotherapy: Data from the EURAP neurocognitive extension protocol
Consistent with previous reports, our results provide evidence for an adverse effect of prenatal exposure to valproate on verbal development. Our finding of relatively weaker performance of VPA-exposed children compared to other ASM exposures in both comprehension of instructions and face memory also suggest that children of mothers treated with VPA are at increased risk for compromised memory functions or altered processing of socially relevant information.
Authors
- Sanjeev V. Thomas (ORCID: https://orcid.org/0000-0001-5307-3551)
- Dina Battino (ORCID: https://orcid.org/0000-0001-5784-9986)
- Torbjörn Tomson (ORCID: https://orcid.org/0000-0003-0554-5352)
- John Craig (ORCID: https://orcid.org/0000-0002-9219-9795)
- Emilio Perucca (ORCID: https://orcid.org/0000-0001-8703-223X)
- Yfke Huber‐Mollema (ORCID: https://orcid.org/0000-0003-0623-1929)
- Anne Sabers (ORCID: https://orcid.org/0000-0001-8925-213X)
- Frank Vajda (ORCID: https://orcid.org/0000-0001-5570-7538)
- Eija Gaily
- Susanna Stjerna (ORCID: https://orcid.org/0000-0003-3278-3524)
Institutions
- Belfast Health and Social Care Trust (GB)
- University of Helsinki (FI)
- The University of Melbourne (AU)
- Helsinki University Hospital (FI)
- Rigshospitalet (DK)
- Karolinska Institutet (SE)
- Helsinki Children's Hospital (FI)
- Kenter Jeugdhulp (NL)
- Austin Health (AU)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Hospital District of Helsinki and Uusimaa (FI)
- Monash University (AU)
Publication Details
- Journal
- Epilepsy & Behavior
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.yebeh.2024.110024
- Citations
- 8
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- GlaxoSmithKline
- Sanofi
- Alere
- Sierra Oncology
- University of Colorado Boulder
- Sanofi-Aventis Deutschland
- UCB Pharma