Real-World Effectiveness of Mepolizumab in Severe Asthma: Results from the Multi-country, Self-controlled Nucala Effectiveness Study (NEST)
Mepolizumab was effective in reducing the burden of SA by significantly reducing CSEs, reducing OCS use and HCRU, and improving lung function and asthma control, which could translate to improvements in health-related quality of life in patients with SA and high OCS dependency in the countries studied. A graphical abstract is available with this article.
Authors
- Riyad Al‐Lehebi (ORCID: https://orcid.org/0000-0002-3232-6668)
- María Laucho-Contreras (ORCID: https://orcid.org/0000-0002-7611-0498)
- Saeed Noibi (ORCID: https://orcid.org/0009-0002-4075-7182)
- Gabriela de Azevedo Abreu (ORCID: https://orcid.org/0000-0003-4420-9116)
- Alejandro Raimondi (ORCID: https://orcid.org/0000-0003-2384-5543)
- Debora França dos Santos (ORCID: https://orcid.org/0000-0003-3917-2291)
- Sevim Bavbek (ORCID: https://orcid.org/0000-0002-7884-0830)
- Juliana Queiroz (ORCID: https://orcid.org/0000-0002-1560-3598)
- Gur Levy (ORCID: https://orcid.org/0000-0002-5115-921X)
- Mona Al‐Ahmad (ORCID: https://orcid.org/0000-0003-2950-5363)
- Venkata Nagarjuna Maturu (ORCID: https://orcid.org/0000-0002-3679-9497)
- Cláudia Soares (ORCID: https://orcid.org/0000-0002-8425-2066)
- Elizabeth A. Garcia (ORCID: https://orcid.org/0000-0002-3453-2625)
- Patricia Fernández (ORCID: https://orcid.org/0000-0002-1702-4637)
- Bassam Mahboub
- Alejandra Galeano Mesa
Institutions
- Dubai Health Authority (AE)
- Alfaisal University (SA)
- Ankara University (TR)
- Universidad de Los Andes (CO)
- Rashid Hospital (AE)
- King Fahd Medical City (SA)
- Kuwait University (KW)
- University of Jeddah (SA)
- Agencia Nacional de Investigación y Desarrollo (CL)
- Fundación Neumológica Colombiana (CO)
- Yashoda Hospital (IN)
- Fundación Santa Fe de Bogotá (CO)
- Secretaría de Salud de Bogotá (CO)
- GlaxoSmithKline (Brazil) (BR)
Publication Details
- Journal
- Advances in Therapy
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1007/s12325-024-02967-x
- Citations
- 17
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.55