Liver damage and muscle injury associated with the use of statins

Pharmacological monitoring with positive and negative effects on the use of medications is an important aspect during the administration of different drugs. Adverse events generated by the misuse of medications have become one of the main causes of death worldwide and an urgent problem in the field of toxicology. Cardiovascular diseases currently occupy the top positions among the main causes of death worldwide, especially in older adults who, burdened by their different comorbidities, find themselves faced with the need to use multiple pharmacological therapies. Among them, statins are widely used to reduce bad cholesterol levels and thus be able to combat the formation of plaque at the coronary level, especially in patients with hyperlipidemia and cardiovascular diseases (CVD). Although the use of statins worldwide generates broad benefits, there are different types of adverse reactions (ARs), including liver dysfunction and muscle damage, that affect the quality of life of people who use them. This review describes the mechanisms, epidemiology and rapid identification of hepatic and muscular effects associated with the use of statins.