Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure
The replication of mechanistic signatures across discovery and validation cohorts closely aligns with the experimental effects of SGLT2 inhibitors. Thus, the actions of SGLT2 inhibitors-to promote autophagy, restore mitochondrial health and production of ATP, promote iron mobilization and erythropoiesis, influence renal tubular ion reabsorption, and normalize cardiac and renal structure and function-are likely to be relevant to patients with heart failure. (EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Preserved Ejection Fraction [EMPEROR-Preserved], NCT03057951; EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction [EMPEROR-Reduced], NCT03057977).
Authors
- Stefan D. Anker (ORCID: https://orcid.org/0000-0002-0805-8683)
- Milton Packer
- Mikhail Sumin (ORCID: https://orcid.org/0000-0002-3827-5793)
- Sandra González Maldonado
- Faiez M. Zannad (ORCID: https://orcid.org/0000-0001-7456-1570)
- James Louis Januzzi (ORCID: https://orcid.org/0000-0002-8338-1798)
- Jürgen H. Prochaska (ORCID: https://orcid.org/0000-0001-5078-9992)
- Maral Saadati (ORCID: https://orcid.org/0000-0002-9378-526X)
- Naveed A. Sattar (ORCID: https://orcid.org/0000-0002-1604-2593)
- Javed Butler (ORCID: https://orcid.org/0000-0003-4267-6933)
- Marina Panova‐Noeva (ORCID: https://orcid.org/0000-0003-2155-8030)
- João Pedro Ferreira (ORCID: https://orcid.org/0000-0002-2304-6138)
- Stuart J. Pocock
Institutions
- Boehringer Ingelheim (Germany) (DE)
- Inserm (FR)
- Universidade do Porto (PT)
- Johannes Gutenberg University Mainz (DE)
- National and Kapodistrian University of Athens (GR)
- Baylor University Medical Center (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- Massachusetts General Hospital (US)
- London School of Hygiene & Tropical Medicine (GB)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Baylor Medical Center at Garland (US)
- Baim Institute for Clinical Research (US)
- German Centre for Cardiovascular Research (DE)
- University General Hospital Attikon (GR)
- Research Institute of Dallas (US)
- Baylor Scott & White Health (US)
- French Clinical Research Infrastructure Network (FR)
- Imperial College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- Université de Lorraine (FR)
Publication Details
- Journal
- Journal of the American College of Cardiology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.jacc.2024.07.013
- Citations
- 21
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 12.03