Altered methylation of imprinted genes in neuroblastoma: implications for prognostic refinement
Aberrant methylation in imprinted regions is frequently occurring in NB tumours and several of these regions have independent prognostic value. Thus, these could serve as potentially important clinical epigenetic markers to identify individuals with adverse prognosis. Incorporation of methylation status of these regions together with the established risk predictors may further refine the prognostication of NB patients.
Authors
- Maja Löfgren
- Johanna Svensson (ORCID: https://orcid.org/0000-0001-9872-5920)
- Medha Suman
- Teresia Kling
- Helena Carén (ORCID: https://orcid.org/0000-0002-8584-555X)
- Susanne Fransson (ORCID: https://orcid.org/0000-0002-9713-3074)
- Per Kogner (ORCID: https://orcid.org/0000-0002-2202-9694)
- Tommy Martinsson (ORCID: https://orcid.org/0000-0002-9403-3123)
- Anna Djos (ORCID: https://orcid.org/0000-0002-5250-2163)
- Jewahri Idris Yousuf
Institutions
- Karolinska Institutet (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1186/s12967-024-05634-5
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancerfonden
- Vetenskapsrådet
- Sahlgrenska Universitetssjukhuset
- Göteborgs Universitet
- Barncancerfonden