The impact of long‐course chemoradiotherapy on the myenteric plexus, neuromuscular functions and responses to prokinetic drugs in the human rectum
Several months after chemoradiotherapy, the rectum was not inflamed and myenteric neuron numbers/phenotype unchanged. However, nitrergic activity was increased relative to cholinergic activity, and prokinetic-like drug activity was lost or greatly reduced. Thus, chemoradiotherapy causes long-term changes in neuromuscular functions and markedly reduces the efficacy of drugs for treating constipation.
Authors
- Sarah Epton (ORCID: https://orcid.org/0000-0002-1610-0271)
- Raj Makwana (ORCID: https://orcid.org/0000-0003-2175-3530)
- Nicholas Baidoo (ORCID: https://orcid.org/0000-0001-7017-2287)
- Alexandra Palmer (ORCID: https://orcid.org/0000-0002-4786-4960)
- Victor Kung (ORCID: https://orcid.org/0000-0002-9166-4181)
- Mohamed A. Thaha (ORCID: https://orcid.org/0000-0002-5043-6107)
- Charles H. Knowles (ORCID: https://orcid.org/0000-0001-9854-6754)
- Gareth J. Sanger (ORCID: https://orcid.org/0000-0002-4231-1945)
- John Broad (ORCID: https://orcid.org/0000-0002-1641-7076)
- Shezan Elahi (ORCID: https://orcid.org/0000-0002-9408-8917)
- Joanne Chin‐Aleong
Institutions
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Royal London Hospital (GB)
- University of Westminster (GB)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1002/ueg2.12653
- Citations
- 3
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Takeda Pharmaceuticals U.S.A.
- Bowel and Cancer Research
- Dunhill Medical Trust
- Age UK