Association Between Antibodies That Bind Epstein-Barr Virus (EBV) gp350 and gH/gL and Shedding of EBV in Saliva From Nasopharyngeal Carcinoma Multiplex Family Members in Taiwan
Elevated levels of Epstein-Barr virus (EBV) gp350 and gH/gL antibodies have been associated with a lower risk of developing nasopharyngeal carcinoma (NPC), although the evidence remains inconclusive and unexplained. We conducted a longitudinal study within a high-risk Taiwanese cohort, analyzing total immunoglobulin against EBV-gp350 and -gH/gL in blood and EBV DNA shedding in saliva. Contrary to our hypothesis-that elevated levels of antibodies previously shown to be associated with a lower NPC risk should result in a decrease in EBV shedding in saliva-higher anti-gp350 antibodies at baseline were significantly associated with detectable EBV DNA in saliva at follow-up (odds ratio [OR], 1.99 [95% confidence interval {CI}, 1.03-3.97]; <i>P</i> = .04). Higher anti-EBV-gH/gL antibodies at baseline were not significantly associated with risk of detectable EBV DNA at follow-up (OR, 0.69 [95% CI, .35-1.32]; <i>P</i> = .26). These findings underscore the complexity of virus-host interactions and emphasize the need for further investigations into their role in EBV-associated diseases.
Authors
- Anna E. Coghill (ORCID: https://orcid.org/0000-0001-7142-7499)
- K. Liu
- Tseng‐Cheng Chen (ORCID: https://orcid.org/0000-0002-3360-0382)
- Wan‐Lun Hsu (ORCID: https://orcid.org/0000-0002-7271-6070)
- Zhiwei Liu (ORCID: https://orcid.org/0000-0002-0136-651X)
- Jeffrey I. Cohen (ORCID: https://orcid.org/0000-0003-0238-7176)
- Allan Hildesheim (ORCID: https://orcid.org/0000-0003-0257-2363)
- Jaap M. Middeldorp (ORCID: https://orcid.org/0000-0002-0765-4125)
- Kelly J. Yu (ORCID: https://orcid.org/0000-0003-3832-6586)
- Wei Bu (ORCID: https://orcid.org/0000-0002-1747-4945)
- Cheng‐Ping Wang (ORCID: https://orcid.org/0000-0001-7872-1463)
- Tim Waterboer (ORCID: https://orcid.org/0000-0002-0616-6963)
- Yin‐Chu Chien
- Chien‐Jen Chen (ORCID: https://orcid.org/0000-0002-6996-9069)
Institutions
- Fu Jen Catholic University (TW)
- National Institutes of Health (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Moffitt Cancer Center (US)
- Genomics Research Center, Academia Sinica (TW)
- Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (CR)
- National Taiwan University Hospital (TW)
- National Institute of Allergy and Infectious Diseases (US)
- National Cancer Institute (US)
- Division of Cancer Epidemiology and Genetics
- University of Pennsylvania (US)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1093/ofid/ofae464
- Citations
- 5
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Science Council
- National Cancer Institute