Metavert synergises with standard cytotoxics in human PDAC organoids and is associated with transcriptomic signatures of therapeutic response
Metavert as a single agent and in combination with irinotecan offers novel strategies for treating pancreatic cancer.
Authors
- Thilo Hackert (ORCID: https://orcid.org/0000-0002-7012-1196)
- Julia V. Mayerle (ORCID: https://orcid.org/0000-0002-3666-6459)
- Christoph Springfeld (ORCID: https://orcid.org/0000-0003-3843-101X)
- Katrin Pfütze
- Stephan Wolf
- Kai Hu (ORCID: https://orcid.org/0000-0002-2900-2961)
- Susanne Roth (ORCID: https://orcid.org/0000-0002-5136-4686)
- Adrian Lim (ORCID: https://orcid.org/0000-0002-4638-9395)
- John P. Neoptolemos (ORCID: https://orcid.org/0000-0002-6201-7399)
- Stephen J. Pandol (ORCID: https://orcid.org/0000-0003-0818-6017)
- Benedikt Brors (ORCID: https://orcid.org/0000-0001-5940-3101)
- Teresa Peccerella (ORCID: https://orcid.org/0000-0001-5520-0243)
- Sadaf Shabbir Mughal (ORCID: https://orcid.org/0000-0003-3468-8467)
- Mouad Edderkaoui (ORCID: https://orcid.org/0000-0002-2549-8242)
- Roma Kurilov
- Georg Beyer (ORCID: https://orcid.org/0000-0002-7607-8264)
- Shigenori Ei (ORCID: https://orcid.org/0000-0002-3233-1635)
- Franco Fortunato (ORCID: https://orcid.org/0000-0002-6711-5828)
- Johannes Hulkkonen (ORCID: https://orcid.org/0000-0002-9517-8527)
- Daniela Merz (ORCID: https://orcid.org/0000-0001-7977-0275)
- Christoph Michalski (ORCID: https://orcid.org/0000-0003-3520-1040)
- Xu Zhou (ORCID: https://orcid.org/0000-0003-4558-4137)
- Jingyu An
- Angela Schulz (ORCID: https://orcid.org/0000-0002-4491-1581)
- Arianeb Mehrabi (ORCID: https://orcid.org/0000-0003-2843-1390)
- Peter J. Bailey (ORCID: https://orcid.org/0000-0002-0857-2041)
- Lenart Zezlina
- Mohammed Al‐Saeedi (ORCID: https://orcid.org/0000-0001-7580-7472)
- Markus W. Büchler
- Frank Bergmann
- Martin Loos
Institutions
- Champalimaud Foundation (PT)
- Cedars-Sinai Medical Center (US)
- Tokai University (JP)
- Universität Hamburg (DE)
- University of California, Los Angeles (US)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Translational Oncology
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1016/j.tranon.2024.102109
- Citations
- 3
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- U.S. Department of Defense
- Bundesministerium für Bildung und Forschung
- Deutsche Krebshilfe
- Heidelberger Stiftung Chirurgie
- National Cancer Institute