Single-cell sequencing reveals glial cell involvement in development of neuropathic pain via myelin sheath lesion formation in the spinal cord
Our study reveals the close relationship between the differentiation block of oligodendrocytes after CCI and their interaction with microglia and astrocytes-mediated myelin lesions and NP. CADM1/CADM1 and NRP-1/VEGFA may serve as potential therapeutic targets for use in the treatment of NP.
Authors
- Zhenyu Yue
- Sen Yin (ORCID: https://orcid.org/0000-0003-1723-5415)
- Shouwei Yue (ORCID: https://orcid.org/0000-0002-5399-9044)
- Xiaoqian Xu (ORCID: https://orcid.org/0000-0002-7579-7902)
- Danyang Li (ORCID: https://orcid.org/0000-0002-7508-6019)
- Hui Wei (ORCID: https://orcid.org/0000-0003-2568-9345)
- Jinlu Li (ORCID: https://orcid.org/0000-0003-3432-9368)
- Kaihong Yang
- Lanlan Gong
- Yikun Wu
Institutions
- Johnson & Johnson (United States) (US)
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2024-08-31
- DOI
- https://doi.org/10.1186/s12974-024-03207-3
- Citations
- 16
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.22
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Natural Science Foundation of Shandong Province
- National Health Commission of the People's Republic of China