Cannabidiol exhibits potent anti-cancer activity against gemcitabine-resistant cholangiocarcinoma via ER-stress induction in vitro and in vivo
The results suggest that CBD exhibits potent anti-cancer activity against gemcitabine-resistant CCA in vitro and in vivo, in part via ER stress-mediated mechanisms. These results indicate that clinical explorative use of CBD on gemcitabine-resistant CCA patients is warranted.
Authors
- Thatsanapong Pongking (ORCID: https://orcid.org/0009-0006-4999-1038)
- Porntip Pinlaor (ORCID: https://orcid.org/0000-0001-7436-3355)
- Kulthida Vaeteewoottacharn (ORCID: https://orcid.org/0000-0001-6557-9680)
- Sirinapha Klungsaeng
- Somchai Pinlaor (ORCID: https://orcid.org/0000-0002-8187-7247)
- Apisit Chaidee (ORCID: https://orcid.org/0000-0001-6495-0951)
- Phonpilas Thongpon (ORCID: https://orcid.org/0009-0006-9185-5611)
- Raynoo Thanan (ORCID: https://orcid.org/0000-0002-9001-1197)
- Chadamas Sakonsinsiri (ORCID: https://orcid.org/0000-0003-0145-8753)
- Kitti Intuyod (ORCID: https://orcid.org/0000-0002-1096-9371)
- Suppakrit Kongsintaweesuk (ORCID: https://orcid.org/0009-0002-6276-5765)
- Naruechar Charoenram
Institutions
- Khon Kaen University (TH)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1186/s12906-024-04610-2
- Citations
- 8
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.26
Funders
- Khon Kaen University
- National Research Council of Thailand