Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity
While BW without obesity had lower Rd than WW, race and obesity did not synergistically impact peripheral IR. Paradoxically, WW with obesity had greater hepatic IR compared to BW. Relationships between SM respiration and IR persisted across a range of body weights. These data provide support for therapies in BW, like exercise, that improve SM mitochondrial respiration to reduce IR and T2D risk.
Authors
- Paul M. Coen (ORCID: https://orcid.org/0000-0002-2805-2115)
- John J. Dubé (ORCID: https://orcid.org/0000-0002-0703-5930)
- Giovanna Distéfano (ORCID: https://orcid.org/0000-0003-1208-5008)
- Frederico G. S. Toledo (ORCID: https://orcid.org/0000-0002-6570-9948)
- Bret H. Goodpaster (ORCID: https://orcid.org/0000-0003-1275-5147)
- Justine M. Mucinski (ORCID: https://orcid.org/0000-0003-4432-6638)
- James P. DeLany (ORCID: https://orcid.org/0000-0003-0366-3849)
Institutions
- University of Pittsburgh (US)
- AdventHealth Orlando (US)
- Translational Research Institute for Metabolism and Diabetes (US)
- Chatham University (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2024-08-29
- DOI
- https://doi.org/10.1210/clinem/dgae600
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.65
Funders
- National Institutes of Health