Inhibition of the P38 MAPK/NLRP3 pathway mitigates cognitive dysfunction and mood alterations in aged mice after abdominal surgery plus sevoflurane
Our study suggests that anesthesia and surgical procedures induce alterations in mood and cognition, which may be intricately linked to the P38 MAPK/NLRP3 pathway.
Authors
- Ziqiang Wu (ORCID: https://orcid.org/0009-0004-3176-8423)
- Tingting Zhou (ORCID: https://orcid.org/0009-0007-3880-4935)
- Baodong Li (ORCID: https://orcid.org/0000-0002-4886-0240)
- Jin‐Meng Lv
- Limin Zhang (ORCID: https://orcid.org/0000-0002-2933-7227)
- Xiaoming Li (ORCID: https://orcid.org/0000-0002-5555-9034)
- Heng-Yue Peng
- Qing-Meng Lu
- Yi-Long Gao
- Yong-Lin Shan
- Luying Wang (ORCID: https://orcid.org/0000-0003-2820-1341)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Hospital of Hebei Province (CN)
- Cangzhou Central Hospital (CN)
- Integrated Chinese Medicine (China) (HK)
- People's Hospital of Cangzhou (CN)
- China Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1016/j.brainresbull.2024.111059
- Citations
- 2
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.84