Radiosynthesis and in-vitro identification of a molecular probe 131I-FAPI targeting cancer-associated fibroblasts
<sup>131</sup>I-FAPI was synthesized with good <i>in-vitro</i> stability and hydrophilic properties. It can be specifically bound by U87 cells. The proliferation and migration of U87 cells can be effectively inhibited. <sup>131</sup>I-FAPI is promising to become a therapeutic probe.
Authors
- Yaxin Tian
- Xiaodong Yu
- Xiaowei Ma (ORCID: https://orcid.org/0000-0002-3062-4063)
- Liang Du
- Qian Zhao (ORCID: https://orcid.org/0000-0002-9305-3667)
- Fengkui Wang
- Yanghongyan Jiang
- Ping Ma
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Ningxia Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-08-30
- DOI
- https://doi.org/10.3389/fonc.2024.1442601
- Citations
- 1
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.28