Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging
Our study indicated that with increasing age, mutations in Enpp1 promote ectopic ossification of spinal ligaments and endochondral ossification in tendons and further aggravate knee degeneration by upregulating hedgehog signaling.
Authors
- Tao Tang (ORCID: https://orcid.org/0000-0002-4863-6660)
- Nguyen Tran Canh Tung (ORCID: https://orcid.org/0000-0002-7757-1878)
- Zhiyu Zhou (ORCID: https://orcid.org/0000-0002-8101-2083)
- Zhengya Zhu (ORCID: https://orcid.org/0000-0002-9250-4251)
- Peng Guo (ORCID: https://orcid.org/0000-0002-2006-6205)
- Fuan Wang (ORCID: https://orcid.org/0000-0002-3063-2485)
- Manman Gao
- Zhongyuan He (ORCID: https://orcid.org/0000-0002-6194-0720)
- Jianfeng Li (ORCID: https://orcid.org/0000-0002-3243-8539)
- Shaoyu Liu (ORCID: https://orcid.org/0000-0003-2824-8780)
- Xizhe Liu (ORCID: https://orcid.org/0000-0002-5658-3626)
- Liang Qian (ORCID: https://orcid.org/0009-0000-7831-3785)
Institutions
- Sun Yat-sen University (CN)
- Dalian Medical University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shenzhen Second People's Hospital (CN)
- University of Toyama (JP)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Bone and Mineral Metabolism
- Published
- 2024-08-30
- DOI
- https://doi.org/10.1007/s00774-024-01543-1
- Citations
- 8
- Primary Topic
- Heterotopic Ossification and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 3.76
Funders
- Natural Science Foundation of Guangzhou City
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen